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QB: Brett Favre, Minnesota: Seattle ranks as the league’s 11th-worst pass defense and has struggled on the road. It allowed Kurt Warner to throw for 340 yards and two scores last game; Tony Romo to pass for 256 yards and three scores in Week 8; and Peyton Manning to pass for 353 yard and two scores in Week 4.

RB: Bernard Scott/Brian Leonard/Larry Johnson, Cincinnati: Scott will reportedly receive most of the carries if Cedric Benson is out with a hip injury. However, Leonard may serve as the back on third-downs or passing situations. If Cincinnati jumps to a sizeable lead, it could elect to use Johnson as the featured back.

RB: Ladell Betts, Washington: He’s the featured back with Clinton

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QB: Kyle Orton, Denver: On paper, Washington’s pass defense is ranked No. 1. However, it has faced only one quarterback (Eli Manning) ranked in the top 16 in passing yards and just one rated in the top 12 (Manning) in passing touchdowns.

QB: Matt Cassel, Kansas City: He threw for 241 yards and one touchdown against Oakland in Week 2’s meeting. He also added 34 rushing yards.

QB: Josh Freeman, Tampa Bay: The rookie passed for 205 yards and three touchdowns in his first NFL start. He’s facing Miami’s fifth-worst pass defense that’s also starting two rookie cornerbacks.

RB: Jamaal Charles, Kansas City: Oakland ranks as the league’s fourth-worst run defense and has yielded the most

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QB: David Garrard, Jacksonville:  Kansas City ranks as the league's fifth-worst pass defense and has allowed the fourth-most passing scores (13). Garrard has shown he could be very productive against a shaky defense when he threw for 323 yards and three scores at home against Tennessee in Week 4.

QB: Matt Cassel, Kansas City: The Jaguars rank in the bottom quarter of pass defenses and have yielded the fourth-most passing scores (13). Cassel travels to Jacksonville aiming for his fourth contest of multiple passing scores.

RB: Correll Buckhalter, Denver: Pittsburgh ranks as the top rushing defense, but is susceptible to allowing receiving yards to a running back. For instance, Adrian Peterson caught

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QB: Marc Bulger, St. Louis: Detroit rates as the NFL's third-worst passing defense and has yielded the second-most passing scores (17). Bulger has struggled this season but fantasy reserve Jason Campbell had his best fantasy day against Detroit. He threw for 340 yards and two scores against the Lions in Week 3.

Matthew Stafford, Detroit: St. Louis ranks as the league's eighth-worst pass defense and has allowed the sixth-most passing touchdowns (11). Stafford is expected to return from his knee injury and has shown he can produce an adequate fantasy day. He threw for 296 yards and one score against Chicago in his last contest.

RB: Tashard Choice, Dallas: Though Marion Barber and Felix Jones are lauded more, Choice has shown

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QB: Chad Henne, Miami: The second-year vet threw for 241 yards and two scores for his best career fantasy day last contest. The Saints have already allowed a young, inexperienced quarterback to pass for a solid fantasy day. Third-year vet Kevin Kolb threw for 391 yards and two scores in Week 2.

QB: Ryan Fitzpatrick, Buffalo: He showed promise when he passed for 116 yards and one score against a tough Jets pass defense last contest. He’s starting in place of an injured Trent Edwards and faces Carolina’s erratic defense. It allowed Donovan McNabb to throw for two scores and Matt Ryan to pass for three touchdowns this season.

RB: Larry Johnson, Kansas City: San Diego ranks as the league’s sixth-worst rushing defense, giving